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Combination prophylaxis versus pharmacologic prophylaxis alone for preventing deep vein thrombosis in hip surgery

Abstract

Purpose

To evaluate the comparative efficacy and safety of combination pharmacologic and graduated compression stockings (GCS) prophylaxis versus pharmacological prophylaxis alone for preventing deep vein thrombosis (DVT) and pulmonary embolism (PE) in hip surgery.

Methods

Relevant publications indexed in PubMed, Cochrane Library, Embase, Web of Science, Wanfang Data, CNKI and Sinomed (CBM) were identified. Appropriate articles identified from the reference lists of the above searches were also reviewed.

Results

Significant differences in the rate of distal DVT were observed between combination prophylaxis and pharmacological groups. When data from Fredin 1989 was excluded no significant difference in the rate of distal DVT was seen between groups. No significant difference in the rate of proximal DVT or PE was observed between combination and pharmacologic prophylaxis groups.

Conclusions

A combination of pharmacological prophylaxis and GCS can decrease distal DVT in the lower extremity when compare to pharmacological prophylaxis alone, but it is not useful in decreasing proximal DVT and PE. If we use currently recommended pharmacologic prophylaxis it is not necessary to combine this with GCS.

Hip Int 2016; 26(6): 561 - 566

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/hipint.5000384

Authors

Feng-Fei Lin, Chao-Hui Lin, Bin Chen, Ke Zheng

Article History

Disclosures

Financial support: None.
Conflict of interest: None.

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Authors

Affiliations

  • Department of Orthopaedic Surgery, Fuzhou Second Hospital, The Affiliated Hospital of Xiamen University, The Teaching Hospital of Fujian Medical University, Fuzhou, Fujian - China

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