Neutrophil to lymphocyte ratio may be a predictive marker of poor prognosis in Legg-Calvé-Perthes disease



Legg-Calvé-Perthes disease (LCPD) is the idiopathic avascular necrosis of the femoral head in childhood. The pathologic changes seen in the femoral head are likely a result of vascular factors. Blood neutrophil to lymphocyte (N/L) ratio is a simple marker of subclinical inflammation. This study aims to to analyse the predictive ability of N/L ratio for the prognosis in LCPD patients.


Patients who had been diagnosed as LCPD from 2008 to 2014 were investigated retrospectively and 40 LCPD patients (33 male and 7 female) and 25 healthy age and sex-matched children (controls) were included in the study. LCPD patients were divided into 2 groups according to expected prognosis (good prognosis expected Herring A and B patients as Group I and poor prognosis expected Herring B-C and C patients as Group II) and healthy children (control) were included in Group III. All the patients’ hematological markers were analysed.


Mean age was 7.1 ± 2.0 years in group I (4.9-12 years), 8.3 ± 2.2 years (4-12.5 years) in group II and 7.8 ± 1.3 years (6-12 years) in group III. Mean values for Groups I, II and III for neutrophil to lymphocyte (N/L) ratio were 1.13 ± 0.65, 1.75 ± 0.95, 1.08 ± 0.37, respectively. The mean neutrophil to lymphocyte (N/L) ratio of Group II was higher than the other 2 groups (p = 0.003).


N/L ratio may give us information about the natural course of LCPD and may be used as independent predictor of prognosis in patients with LCPD.

Hip Int 2016; 26(6): 598 - 601




Burak Kaymaz, Kadir Büyükdogan, Nazan Kaymaz, Erkam Kömürcü, Umut Hatay Golge, Ferdi Goksel, Mehmet Cemalettin Aksoy

Article History


Financial support: None.
Conflict of interest: None.

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  • Department of Orthopaedics and Traumatology, Çanakkale Onsekiz Mart University, Medical School, Çanakkale - Turkey
  • Department of Orthopaedics and Traumatology, Hacettepe University, Medical School, Ankara - Turkey
  • Department of Paediatrics, Çanakkale Onsekiz Mart University, Medical School, Çanakkale - Turkey

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